According to Keith Weissman, AIPAC was behind the first set of sanctions imposed on Iran, back in 1995, when Weissman helped to write the Executive Order that Bill Clinton signed, and the later Libya and Iran Sanctions legislation that established the Order as law.
As Weissman explained in the linked video, those sanctions on Iran were "a waste of energy," were "ineffective," but did harm American interests and did derail the Khatami government's outreach toward repairing Iranian-American relations. With regard to the harm to American interests, Weissman noted that Conoco was forced to forgo a very favorable contract to develop Iranian oilfields. Robin Wright has testified in other places that that lost contract cost several thousand American jobs.
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