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  •  since I don't have time to go over the.... (1+ / 0-)
    Recommended by:
    Matt Z

    .... links and such, what's the summary?

    From what you said, I assume they're looking at ways to utilize the genes for vascularization without also getting the genes for uncontrolled runaway growth.  

    Is that approximately right?  And has there been progress?

    "Minus one vote for the Democrat" equals "plus one vote for the Republican." Arithmetic doesn't care about your feelings.

    by G2geek on Fri Sep 30, 2011 at 06:55:34 PM PDT

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    •  Tumor growth and tumor vascularization... (0+ / 0-)

      ...are linked, but separate, concepts.

      Some tumors (not all) grow quickly, and become metastatic, in part because they secrete biomolecules (cytokines) that encourage the growth of blood vessels in and around them.  The better the blood supply, the better chance the tumor has to grow, and quickly, and to spread.

      But uncontrolled runaway growth is due to genetic changes that, in large pat, have no relation to vascularization.  In some cases, tumor cells' cell cycle becomes dysregulated, so that the cells cannot respond to normal signals to stop replicating.  In other cases, the tumor cells lose the ability to perceive other cells around them.  Normal cells' growth is generally inhibited by contact with other cells.  In many cases, the precise genetic abnormality leading to tumorigenesis is not known, but in some cases, such as multiple myeloma, there are very distinct and well-known genetic rearrangements that, when they occur, are very bad signs - like a train rolling downhill without brakes, it becomes almost impossible to stop the cancer.

      In any event, in answer to one of your questions above, one well-known biomolecule, a cytokine called vascular endothelial growth factor (VEGF), encourages a type of cell called endothelial cells to form vessels.

      We reach for the stars with shaking hands in bare-knuckle times.

      by TheOrchid on Fri Sep 30, 2011 at 10:21:37 PM PDT

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      •  OK, got it. (0+ / 0-)

        I didn't want to use the word "vascularization" in my original post because that's identified with cancer, and would put a bad vibe on the concept for some readers.

        "Minus one vote for the Democrat" equals "plus one vote for the Republican." Arithmetic doesn't care about your feelings.

        by G2geek on Sat Oct 01, 2011 at 07:40:12 PM PDT

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