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View Diary: Electronic cigarettes: new laws prompted by hysteria and misinformation (202 comments)

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  •  Wrong (0+ / 0-)

    Nicotine is a poison.   It does major damage to your arteries and is a carcinogen.

    There are other toxic substances in cigarettes, but nicotine is the worst.

    Here is a challenge.   Go and get your self some rolling papers, or cigarette tubes.  Now instead of putting in tobacco, put some mint in there.   This will satisfy the physical action needs of smoking.  However you will discover that it will do nothing for your nicotine cravings.

    We must all hang together, or assuredly we shall all hang separately - Ben Franklin

    by DanD on Thu Dec 01, 2011 at 07:43:44 AM PST

    [ Parent ]

    •  You're wrong (5+ / 0-)

      Nicotine is not the worst. It is the combination of nicotine and by-products of smoke working together that make nicotine dangerous:

      Tobacco smoke contains the monoamine oxidase inhibitors harman, norharman,[23] anabasine, anatabine, and nornicotine. These compounds significantly decrease MAO activity in smokers.[23][24] MAO enzymes break down monoaminergic neurotransmitters such as dopamine, norepinephrine, and serotonin. It is thought that the powerful interaction between the MAOI's and the nicotine is responsible for most of the addictive properties of tobacco smoking. [25] The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats.[26]

      Chronic nicotine exposure via tobacco smoking up-regulates alpha4beta2* nAChR in cerebellum and brainstem regions[27][28] but not habenulopeduncular structures.[29] Alpha4beta2 and alpha6beta2 receptors, present in the ventral tegmental area, play a crucial role in mediating the reinforcement effects of nicotine.[30]

      Nicotine by itself does not cause damage to cell or cancer. However, it has been shown to impede the body's response to fighting mutant cells.

      The carcinogenic properties of nicotine in standalone form, separate from tobacco smoke, have not been evaluated by the IARC, and it has not been assigned to an official carcinogen group. The currently available literature indicates that nicotine, on its own, does not actively induce the development of cancer in healthy tissue and has no mutagenic properties. However, nicotine and the increased cholinergic activity it causes have been shown to impede apoptosis, which is one of the methods by which the body destroys unwanted cells (programmed cell death). Since apoptosis helps to remove mutated or damaged cells that may eventually become cancerous, the inhibitory actions of nicotine creates a more favourable environment for cancer to develop.[60]

      Now think about this: if a person QUITS SMOKING, do they not SIGNIFICANTLY reduce cell mutations? Do we really need a study to prove that inhaling nicotine is less dangerous than inhaling tar and the hundred other chemicals in cigarettes?

      If you feel the need to fight something, fight cigarettes, not those who are making the attempt to QUIT the toxic sticks. Your idea that nicotine is more dangerous than inhaling tar is laughable.

      Inquiry that does not achieve coordination of behaviour is not inquiry but simply wordplay - Richard Rorty

      by BuckMulligan on Thu Dec 01, 2011 at 01:57:43 PM PST

      [ Parent ]

    •  you're just flat-out wrong, and (0+ / 0-)

      need to do some research. you have absolutely no idea what you're talking about.

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