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View Diary: Good News from Alzheimer's Researchers they may have found the magic bullet (164 comments)

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  •  Caution! (8+ / 0-)

    The mice have been engineered to over-express amyloid like crazy. Most human AD patients do not over-express amyloid. There is a serious controversy as to whether amyloid is a driver of AD or just a marker. Nevertheless it is great to be able to test another drug. Oh, and niacin doesn't cure AD no matter how cheap it is.

    Fructose is a liver poison. Stop eating it today.

    by Anne Elk on Thu Feb 09, 2012 at 08:41:24 PM PST

    •  And I thought it was tau (1+ / 0-)
      Recommended by:
      NepentheRising

      that was expressed before amyloid. That spreads from neuron to neuron.

      Americans, while occasionally willing to be serfs, have always been obstinate about being peasantry. F. Scott Fitzgerald, the Great Gatsby

      by riverlover on Fri Feb 10, 2012 at 01:42:58 AM PST

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      •  That's a good point (1+ / 0-)
        Recommended by:
        riverlover

        because I think that it leads to a different conclusion about how to arrest the progression of the disease. Lots of news on tau recently.

        'You give me a water board, Dick Cheney and one hour, and I'll have him confess to the Sharon Tate murders.' -Jesse Ventura

        by NepentheRising on Fri Feb 10, 2012 at 04:12:36 AM PST

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      •  Yeah, that's certainly and issue. (1+ / 0-)
        Recommended by:
        riverlover

        But think about this: where does AD really come from? No researcher has assembled a cogent narrative that seeks to explain why the brain just decides to make plaque and tangles in one individual and not in another. My feeling is that AD derives from some kind of fault induced in cell-to-cell signaling.

        Fructose is a liver poison. Stop eating it today.

        by Anne Elk on Fri Feb 10, 2012 at 09:00:56 AM PST

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