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View Diary: Women in Science: Rosalind Franklin 1920-1958 (50 comments)

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  •  Actually unlikely. (4+ / 0-)

    Pauling's brilliant deduction of the alpha helix was based largely on intuition and his profound knowledge of structural chemistry; but he did not have at hand the theory helical diffraction (citation in my other post this thread.)  I credit Crick at least for having been a co-developer of that very essential theory, which enabled the correct determination of helical parameters in B DNA.

    Pauling was in a sense flying blind.  Also large molecule crystallography was in its infancy -- the first true solution of a protein structure (sperm whale myoglobin) wasn't achieved until 1963 (by Perutz and Kendrew).  Crick also figured largely in the development of the 'heavy atom isomorphous replacement method' that was required to solve the so-called phase problem in macromolecule crystallography, and was critical for the myoglobin structure.

    (More on the phase problem another day, if anyone is actually interested, which I somewhat doubt.)

    The hungry judges soon the sentence sign, And wretches hang, that jurymen may dine.

    by magnetics on Thu Nov 15, 2012 at 12:01:15 AM PST

    [ Parent ]

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