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View Diary: Another bird flu to watch for... H7N9 in China (178 comments)

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  •  Depends on what you mean by "receptors" (2+ / 0-)
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    Greg Dworkin, kaliope

    I suppose - since NA does the same thing in both cases - i.e., cleave sialic acids (I guess the sialic acid could be considered the "receptor").

    Just, in the early stage loss of sialic acids from mucus changes its biophysical properties, allowing easier penetration of the virus.

    Here's an early paper about that  

    And here's something else that might be relevant (it specifically mentions the word "receptors" . . . )

    •  yeah, the N isn't just there for the ride (5+ / 0-)

      it interferes with the mucociliary layer, "baring" the cell membrane.  What I meant is that is seems to be nonspecific, you don't need the 'right kind' of receptor on the cell to work.

      "Politics is the art of looking for trouble, finding it everywhere, diagnosing it incorrectly and applying the wrong remedies." - Groucho Marx

      by Greg Dworkin on Sun Apr 28, 2013 at 06:38:55 AM PDT

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    •  I should learn grammar so my posts (3+ / 0-)

      make sense  - but read the links, they're a bit better.

      The bigger point here is that if Tamiflu (and other neuramindase inhibitors) work at a very early rather than late stage of infection, they should be better drugs . . .  (for the life of me, I could never figure out how the conventional way that neuramindase inihibitors are purported to work could ever be at all useful or effective)

      •  Should have said - sialic residues are the (0+ / 0-)

        substrate for neuraminidase, which is an enzyme that cleaves sialic acid residues.

        Usually "substrate binding" is used when an enzyme acts on a compound, changing it irreversibly.

        Usually "receptor binding" is used when a molecule on one side of a membrane binds to a protein, which transfers the information across the membrane in some way.

        The size of a molecular entity that binds to a receptor can vary over a very wide range. It could be a small molecule like caffeine, or it could be a hormone, or it could be antibody, or it could be an LDL particle, or it could even be a cell, such as an activated T-cell.

        "They did not succeed in taking away our voice" - Angelique Kidjo - Opening the Lightning In a Bottle concert at Radio City Music Hall in New York City - 2003

        by LilithGardener on Mon Apr 29, 2013 at 01:18:39 PM PDT

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    •  No - sialic acids are the substrate (0+ / 0-)

      There are proteins that recognize and bind to sialic acid residues.

      "They did not succeed in taking away our voice" - Angelique Kidjo - Opening the Lightning In a Bottle concert at Radio City Music Hall in New York City - 2003

      by LilithGardener on Mon Apr 29, 2013 at 01:12:35 PM PDT

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