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  •  The Geogre (2+ / 0-)
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    The Geogre, second gen

    I have a friend who is a diabetic and suffers from severe neuropathy. She was using opiates, now her Dr. has given her Lyrica. It helps her pain but has made her an agoraphobic with other little tics and twists. It, like Neurontin before it, is a drug that fucks with the brain.

    It's terrible. How do you give up something that allows you to move, gives you real relief some of the time, some relief most of the time? How does she balance the pain with the new set of symptoms?

    "Humidity built the snowman. Sunshine brought him down" John Prine

    by high uintas on Sun Jun 23, 2013 at 10:52:18 AM PDT

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    •  Gabapentin/Neurontin was Vitamin G (2+ / 0-)
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      high uintas, second gen

      That stuff
      1. worked
      2. had a very low side effect profile.
      However, it had two major drawbacks:
      1. It went off patent.
      2. It only worked a bit.

      Personally, I'd be happy to be put back on "vitamin G." I never had a day's trouble with it, and it was inexpensive. It was well studied specifically with diabetic neuropathy. Unfortunately, it did nothing to stop the progress of the neuropathies, while some combination of IGF-I and a blocking protein (IGFBP-3?) might, so the chase has been on for the horizon again.

      Something we're not supposed to talk about is that high hoppiness beers help with nerve pain. It's actually clinically proven. I can also report some, um, anecdotal support for the proposition. This doesn't mean Bud. It means anything labeled "IPA."

      Everyone's innocent of some crime.

      by The Geogre on Sun Jun 23, 2013 at 11:09:02 AM PDT

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      •  Interesting (2+ / 0-)
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        The Geogre, second gen

        I took "vitamin G" for nerve pain for awhile after I trashed my wrist. The screws that held my external fixator were touching big nerves and I felt like my hand was in a beehive. It worked, but it made me very ADD with a dash of OCD and just plain stupid. It really did mess with my ability to do things like pay bills or remember to turn off the stove.

        The hop thing is intriguing. I know that hops and pot have some chemical relations. We happen to grow them because mr.u brews his own. I wonder about using hops as a medicine?? I need to read some. My friend w/nerve pain is a rare German who is not a big beer fan. Maybe she could change.

        "Humidity built the snowman. Sunshine brought him down" John Prine

        by high uintas on Sun Jun 23, 2013 at 11:22:41 AM PDT

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      •  Oh, man. I took Neurontin for bipolar and (1+ / 0-)
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        The Geogre

        seizure disorders. HATED it. I would be driving along, and notice that the light was red, and there were cars going through the intersection. "Huh, look at those cars. . . Oh, I guess I should have stopped. . . " as I was looking in the rearview mirror at all the cars. I have no idea how I didn't get killed. I had only made it up to 900 or 1200 mg.

        My daughter is currently taking 2800mg! for migraines. She says it doesn't affect her at all.

        I'd like to start a new meme: "No means no" is a misnomer. It should be "Only 'Yes' means yes." Just because someone doesn't say "No" doesn't mean they've given consent. If she didn't say "Yes", there is no consent.

        by second gen on Sun Jun 23, 2013 at 11:55:25 AM PDT

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        •  Side effect profiles, I guess (0+ / 0-)

          Both of these stories illustrate, I suppose, how idiopathic side effect profiles can be. I was on 300 bid, and I noticed no effects at all. On the other hand, I notice effects from all the anti-depressants -- serious side effects. Similarly, morphine does nothing but make me sleep, but other people get giggly and cosmic.

          At 1200 mg a day, you're in serious dosages -- in the epileptic range. (Also, Neurontin isn't really indicated for bipolar. I.e. it was never supposed to be very effective for it in the first place.)

          I just found it a lot less toxic than, for example, Lyrica. Lyrica is an example of the drugs that were formerly reserved for patients who were suicidal or homicidal, and now they ("Abilify" is a real turkey in this regard, and "Pristiq" may be the most evil of them all) are for general conditions? hGH is for normal conditions, too, if the marketeers have their way.

          Everyone's innocent of some crime.

          by The Geogre on Sun Jun 23, 2013 at 06:52:19 PM PDT

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