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View Diary: Can Antioxidants be Bad for You? (117 comments)

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  •  I found the article and it is byresearchers who (1+ / 0-)
    Recommended by:
    raoul78

    have a lot of experience with this topic. Published in Nurtirents volume 5, number 12,pages 5161-5192 as found here. Free pdf download but here is the abstract:

    Abstract: Research progress to understand the role of vitamin C (ascorbic acid) in human health has been slow in coming. This is predominantly the result of several flawed approaches to study design, often lacking a full appreciation of the redox chemistry and biology of ascorbic acid. In this review, we summarize our knowledge surrounding the limitations of common approaches used in vitamin C research. In human cell culture, the primary issues are the high oxygen environment, presence of redox-active transition metal ions in culture media, and the use of immortalized cell lines grown in the absence of supplemental ascorbic acid. Studies in animal models are also limited due to the presence of endogenous ascorbic acid synthesis. Despite the use of genetically altered rodent strains lacking synthesis capacity, there are additional concerns that these models do not adequately recapitulate the effects of vitamin C deprivation and supplementation observed in humans. Lastly, several flaws in study design endemic to randomized controlled trials and other human studies greatly limit their conclusions and impact. There also is anecdotal evidence of positive and negative health effects of vitamin C that are widely accepted but have not been substantiated. Only with careful attention to study design and experimental detail can we further our understanding of the possible roles of vitamin C in promoting human health and preventing or treating disease.
    Keywords: vitamin C; ascorbic acid; cell culture; animals; human; study design

    Life is just a bowl of Cherries, that stain your hands and clothes and have pits that break your teeth.

    by OHdog on Thu Jan 30, 2014 at 02:37:03 PM PST

    [ Parent ]

    •  I agree with this part (3+ / 0-)
      Recommended by:
      ChemBob, OHdog, slouchsock
      There also is anecdotal evidence of positive and negative health effects of vitamin C that are widely accepted but have not been substantiated. Only with careful attention to study design and experimental detail can we further our understanding of the possible roles of vitamin C in promoting human health and preventing or treating disease.
      The general purpose of my diary was to point out that there is an awful lot we don't really know about human biology and nutrition, and in some cases (such as with Vit E and NAC in this study) things that everyone knows to be good for you may, in certain cases, not be.  

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