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View Diary: Dichloroacetate Redux: A Cancer Primer (53 comments)

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  •  You'd be surprised ;-) (1+ / 0-)
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    Most big pharma companies have "Natural Products" departments.  Botanists collect samples from around the world and researchers study these biologicals for potent drugs.  For example, taxol was originally isolated from the bark of a pacific yew tree.  Rapamycin, a transplant anti-rejection drug and the coating of many stents, was isolated from a fungus in the soil from Rapanui (Easter Island).  A cacer therapy was isolated from vinca plants.  Big Pharmas have databases and compound libraries that they can use to find the drug to fit the target.  It doesn't matter to us where the sucker comes from.  To us, it is just a representation of atoms and bonds.  After we find out what works, we find out how it works and then we try to make it work better.  Most biologicals need to be modified to be potent enough so you don't have to take massive quantities of it and risk serious side effects.

    -3.63, -4.46 "Choose something like a star to stay your mind on- and be staid"

    by goldberry on Sat Feb 03, 2007 at 11:14:50 AM PST

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