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View Diary: Pique the Geek 20090621.  Drugs of Abuse III:  the Psychedelic Indoles (143 comments)

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  •  There are several natural (3+ / 0-)

    products with this property.  The Harmala alkaloids do the same thing.

    I am glad that the structural formulae are making sense.  These are only crude representations of the actual truth, however.  What is important is the three dimensional electronic density structure of these materials, and, unfortunately, these formulae are almost impossible to interpret unless one is a trained physical chemist or chemical physicist (I am the former).  That is the real "lock and key" aspect of why some drugs bind to a receptor without triggering it (a competitive antagonist), bind to it and triggers it (a competitive agonist), or binds to in and partially block and partially activates it (a mixed antagonist/agonist).  The best that I could do was show the gross structural formulae.

    This is why, for example, drugs as different structurally as mescaline and DMT both bind to the 5-HT2A receptor and act as agonists, but have radically different structures.  There electronic density maps are much closer than is apparent from their structures.

    So, take a few minutes and tell us about the birds.  You know that I love nature.  I hope that you have pictures!

    Warmest regards,

    Doc

    Time for real health care reform, not just to patch the patches.

    by Translator on Sun Jun 28, 2009 at 08:42:27 PM PDT

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    •  I do have a pic, (6+ / 0-)
      Recommended by:
      42, G2geek, Translator, C Barr, frosti, Larsstephens

      not from tonight though. It was too dark for good pictures tonight.

      I went out to my family's property; dad was working on putting in plants there and making sure nothing dies from the heat (high 100s F). I brought some sausages out for grilling over the fire pit we have out there.

      While we were eating, we noticed a whinnying sound, then a juvenile Screech Owl flew in over us and landed on a limb right above my head. Then another came in, and then the two adults.

      The 4 owls moved one by one to the bird bath, and started drinking. A fifth owl showed up, and all five spent a good 20 minutes taking turns bathing in the water we put out.

      Here's a pic of one of the owls roosting during the day.

      No more theocracy - Long live the Green Revolution! (-10.00,-8.87)

      by Texas Revolutionary on Sun Jun 28, 2009 at 08:54:00 PM PDT

      [ Parent ]

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