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View Diary: Daily Kos Gulf Watchers ROV #184 - BP's Gulf Catastrophe (308 comments)

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  •  Just remembered something about promoters - (3+ / 0-)
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    rubyr, peraspera, Yasuragi

    in cancer formation chemicals can be divided into initiators and promoters. Initiators make the first hit that starts the process but it may lie indolent until something stirs it up. That "something" is called a promoter and the aromatic hydrocarbons are among those. I wonder if there was a pre-existing cancer that was promoted by the ash he was exposed to?

    •  That's interesting... (0+ / 0-)

      so, are most of these chemicals in hydrocarbons promoters or inducers?  And if you have enough promoters, can they induce?  Is there a fuzzy line between promoter and inducer?  Can they both promote in small amounts and induce in large ones?

      "Katrina was no puddle and this is not a leak." Inspired by Another American Lie

      by khowell on Fri Jul 09, 2010 at 05:20:40 AM PDT

      [ Parent ]

      •  The chemistry gets a little fuzzy. Remember that (1+ / 0-)
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        it is specifically the aromatic hydrocarbons that can do it - there is not a lot of aromatic hydrocarbon in crude oil. The saturated ones (alkanes, like octane) definitely don't do it.

        Some of the compounds (not limited here to hydrocarbons) have quite clear roles as either one or the other. You can apply as much of some initiators as you like, and you won't get a cancer until you follow it with a promoter. Conversely you can apply as much promoter as you like to an unexposed animal and it won't develop cancer. I don't know if there are some compounds with weak initiator and strong promoter activity or vice versa.

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