As someone who is well aware of the inaccessibility of regular Big Pharma medicines in poor countries (Big Pharma are there to make money they are seldom Humanitarian and when they are they are at an insignificant levels).
I proposed accessible medicine for the common of mortal wherever they are and most of the time freely available.
I am not a qualify GP, I am just an Indigenous Medicinal Man that have done exhaustive studies for decennia’s on traditional medicines used in many cultures and I will therefore only promoted those that have managed to get duly corroborated by Scientific Studies that have managed to be done via what most of the time are Approval Agencies control by the Big Pharma.
Do no misunderstand me, I have worked with many patients that were relieved or cured by big Pharma medicines, but I have seen many being put six feet under and get more sick by these "duly pseudo scientifically authorized medicine". The problem in most of the countries is that Scientific Institutions became through decennia’s simple subjects of Big Pharma Budget and Influences.
So Consumers Beware.
I have to add a <disclaimer tough, because <strong>sometimes Traditional or Alternatives medicines have been often used and promoted by the same greedy spirit of Big Pharma and have been presented on false or distorted pretentions or misleading information’s.
So again Consumers Beware from all those money makers, but do not disregard the pertinence of rightfull pretentions of some of their proposed medicines, but make your own opinion as responsable adults, to not become the baby spooned feed by greedy usurpators, whatever side they are.
Remember, if Big Pharma Medicines becomes non-available for some reasons, better remember these milleniums Natural medicines proven efficiency.
Research done in June 2006
Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.
The anti-inflammatory properties of the curcuminoids have been demonstrated in a number of in vitro and in some animal studies. These substances are widely used in India and Indonesia for various inflammatory conditions.
In vitro, curcumin inhibits the production of such pro-inflammatory cytokines as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-8, among other anti-inflammatory actions.
Turmeric has been attributed a number of medicinal properties in the traditional system of medicine and its internal as well local use has been advocated.
The major claims have been for use as antiseptic, cure for poisoning, eliminating body waste products, for dyspesia, respiratory disorders and cure for a number of skin diseases including promotion of wound healing.
Recent studies have confirmed some of the older claims and brought out several new useful properties.
Curcumin, curcuminoids and essential oils are the major active constituents. The main activities have been found to be anti-inflammatory, hepatoprotective, antimicrobial, wound healing, anticancer, antitumor and antiviral.
Different extracts of turmeric and also curcumin have been tried clinically in several diseased conditions with gratifying results.
Possible side effects/ adverse effects:
Curcuminoids should be avoided by those hypersensitive to any component of a curcuminoid-containing supplement.
Curcuminoids may stimulate bile production in some. The volatile oil of turmeric is thought to be responsible for the bile-stimulating activity of turmeric, but this has not been conclusively established.
Therefore, curcuminoids are contraindicated in those with bile duct obstructions and those with gallstones.
Pregnant women and nursing mothers should avoid curcuminoid supplemention.
Those with gastroesophogeal reflux disease (GERD) and those with a history of peptic ulcer disease should exercise caution in the use of curcuminoid supplements.
Curcuminoids may have antithrombotic activity in some. Therefore, those on warfarin or anti-platelet drugs should exercise caution in their use. Cancer patients should only use curcuminoid supplements under medical supervision.
Curcuminoid supplements must be taken with food. Curcuminoids may cause gastric irritation and ulceration if taken on an empty stomach.
Adverse reactions of supplements principally comprised of curcuminoids are mainly gastrointestinal and include epigastric distress and nausea. There is one report of transient giddiness following curcuminoid ingestion. Abnormal liver tests have been reported in rats but not humans, and transient hypotension has been reported in dogs but, again, not in humans.
Curcuminoids may cause gastritis and peptic ulcer disease if taken without food.
INTERACTIONS WITH DRUGS
Chemotherapeutic agents: In animal studies, curcumin was found to enhance the antitumor effect of cisplatin against fibrosarcoma. It was also found to decrease the clastogenic effect of cisplatin. Also in animal studies, curcumin was found to decrease the nephrotoxicity due to doxorubicin and to decrease chromosomal aberrations due to bleomycin.
Anti-platelet drugs: Curcuminoids may enhance the action of anti-platelet drugs.
Warfarin: Curcuminoids may enhance the anticoagulant effect of warfarin.
Where to get it (food or supplement containing it, etc):
Curcumin is a constituent of the common kitchen spice Tumeric. Health food stores and vitamin suppliers should have the standardized supplement in tablet and capsule form.
DOSAGE AND ADMINISTRATION
Curcuminoid supplements are available that contain curcumin at 70 to 75%, demethoxycurcumin at 15 to 20% and bisdemethoxycurcumin at about 3%. Doses used range from 500 to 4000 milligrams daily, and they are taken with meals.
Curcuminoids taken on an empty stomach may cause gastric distress.
IMPORTANT NOTE RE: BIOAVAILABILITY OF CURCUMIN
Medical Abstract Title:
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
(Piperine is found in black pepper. It is available in supplement form, Further information can be found here: http://www.pdrhealth.com/... It does have significnat interactions with some prescription drugs, so if you decide to use it, please read the PDR site first for possible interactions and other issues, and dosage levels.)
More to come as I am now reorganising my reasearch and collegues researches from now unused computers and hundreds of CD<s.</p>
I wish to express my Gratitude to Old time COllegues Shannon and LMonty and others with whom I have worked in Tandem since so many years at curevents.com and flutrackers.com
The Hindi (a language often spoken on the India subcontinent) name for Turmeric is Haldi.
Form the old fluwiki.com
INFORMATION DERIVED FROM: The Physician’s Desk Reference website
IMPORTANT NOTE: BIOAVAILABILITY OF CURCUMIN
Curcumin is poorly absorbed following ingestion in mice and rats. In these animals, 38 to 75% of an ingested dose is excreted directly in the faeces. Absorption appears to be better with food.
It has been demonstrated (Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS Planta Med. 1998; 64(4):353–356) that piperine improves absorption of curcumin. Piperine is found in black pepper. It is available in supplement form, Further information can be found here: http://www.pdrhealth.com/... It does have significant interactions with some prescription drugs, so if you decide to use it, please read the PDR site first for possible interactions and other issues, and dosage levels.)
Curcumin is the compound that gives turmeric spice its bright yellow appearance. It has been used in herbal medicine for a variety of inflammatory conditions, including fever, arthritis, and psoriasis. Curcumin not only blocks TNF, but it is an inhibitor of the MAPK p38 system.
At present, the Pubmed research database identifies 110 citations when searching for "MAPK curcumin" while the search phrase "TNF curcumin" returns 82 results. Review of these articles makes it clear that curcumin holds great promise as an agent that may reduce the lethal effects of the avian flu cytokine storm.
Curcumin is quite inexpensive.
Absorption of curcumin is modest to poor, but can be increased when co-administered with piperine (a compound found in various species of pepper, including the black pepper found in most kitchens). PMID: 9619120 Several commercial formulations of curcumin include piperine (sometimes called bioperine). Piperine itself inhibits TNF, IL-1, IL-6 and other inflammatory cytokines. PMID: 15531295
While it is best to store it at room temperature, it will not be completely inactivated under the un-refrigerated conditions that would destroy the potency of some expensive pharmaceutical TNF blockers. Unlike the pharmaceutical TNF blockers, curcumin is associated with a reduced risk of many types of cancer. In particular, lab studies have shown that curcumin induces apoptosis (programmed cell death) in several types of lymphoma.
For access to my research and many of my collegues here is the link