Random but non-obvious things I think will happen. Eventually. Perhaps.
1. Mormonism will become the dominant religion of the US. I hope not, but it's one of the few religions that seem serious about growing - and the fact that both its mythology and literal history is US-centric gives it a cultural advantage in this country over the course of deep history. And as it seems remarkably able to spread internationally, the tourist pilgrimages of global Mormons to this country would add economic impetus to its expansion. Mormonism is a truly odd phenomenon. Every single Mormon I've ever met has been a genuinely decent person, despite the incongruous ugliness of their politics and utterly moronic, demonstrably false beliefs. Eh, we could do worse.
2. Drug cartels will evolve into semi-legitimate, wealth-backed political parties combining economic conservatism with social libertarianism, primarily in Mexico but with considerable influence beyond. All politics is fundamentally based in economics, and the one thing the War on Drugs has proven beyond all doubt is that the demand for drugs is totally impossible to limit in any meaningful way. When people are happy and prosperous, they do drugs for fun. When people are oppressed, or poor, or afraid, they do drugs to escape. Like energy sources, drugs are a Spice that Must Flow. And like all failed counterinsurgencies, the War on Drugs will be replaced by policies that are accommodative and increasingly legitimize those elements in the cartels that keep the body count to a minimum while allying with authorities to crush those who act like warlords. The evolution of the "reasonable" cartels into political parties might have a similar process to that of the IRA/Sinn Fein.
3. There will be professional sports teams called the Nazis and the Commies, with a theatrically-arranged rivalry between them. There will be people of all races on the Nazi team, and the Commies will make lots and lots of money through capitalist hawking of merchandise. Naturally this will only happen when the memory of World War 2, the Holocaust, and the Cold War is no longer in the living world. I'm not joking about this, BTW, I really think it will happen, albeit not any time soon. There's already a spate of incredibly ignorant, superficial Hitler-themed stuff going on in Asia because they're culturally removed from the European side of WW2. Some day the titanic struggles and tragedies of WW2 will be reduced to a silly sports thing.
Just think about the fact that today there are teams called the Vikings - basically named after mass-murdering home-invasion robbery crews; and the Pirates/Raiders/Buccaneers - thieves and murderers who even to this day exist and cause mayhem off the East coast of Africa; and Spartans, who had a racial purity and militarist ideology with remarkable similarities in cruelty and violent aesthetics to Nazism. But the historical monsters behind the names are dust, so we make their memory into something innocuous. And there's nothing wrong with that as long as real history is still remembered along with the pop culture trivializations.