[Usual caveats: Yes, 2 years, long time, etc etc anything can change....Hillary might not run and Dems might nominate Cuomo instead, etc. For purposes of this post, assume Hillary runs with a good VP candidate and a good campaign team]
With news of Obamacare starting to poll well (actually, it's never been that bad, a sizeable 15% has always wanted an even more aggresive Obamacare) and millions being covered, I have to say this is bad news for the GOP. As Kos, Jed and other Kossites have pointed out, now they're starting to unskew. That fact speaks louder than anything they say. Big mistake from them, they should've listened to David Frum who warned them that since they refused any co-ownership of healthcare reform, that it'd be their Waterloo, not Obama's.
They already have the demographic issues, toss in Obamacare which will be popular and have an existing constituency by 2016 and Democrats are starting the presidential election with huge head start. Even forgetting 2014, if Democrats are brave and strategic this mid-term election, they can minimize losses--hell, they don't have to hold up "O B A M A C A R E" signs, just do like what Lundgren is doing in Kentucky and talk about the benefits of healthcare.
Republicans are IDIOTS. The politically smart move would've been to co-opt this and then boast that they prevented the libruls from putting in communist single payer. Now they have ZERO policy space to do anything about healthcare.
Picture the position their 2016 presidential candidate is going to be in: ANY GOP candidate will have to promise to repeal Obamacare in the primaries. Their far right candidates, Erik Erikssons and Rush Limbaughs, and Club for Growths will not let anyone try and weasel out--all out repeal it must be. But this is 2016, not 1996--you don't get pull out the etch-a-sketch and "run to the center", they will not be able to unsay that stuff in time for the general.
Hell, RIGHT NOW there is a shit ton of material ready. Democratic senators defending seats this November should demand whether their GOP opponents agree with Barasso that the white house is "cooking the books". This is simple folks--make them say over and over that they will repeal Obamacare, straight from the horses mouth. The GOP may win 2014 (I think they're slightly too giddy and overconfident) barely, but 2016 will be a massacre for them.
The schadenfreude will be awesome, couldn't happen to a more deserving bunch.