HERE is the research write-up, in readable English, as published at Medscape — no paywall, you only might have to register in order to read it.
The original med journal article of the research is HERE but it might take going via Medscape to get full-text.
Quoting the initial paragraphs of the write-up:
Anyone with fibromyalgia can tell you it hurts, but no one can yet explain what causes all those aches.
A study published in Pain Reports adds a new piece to the puzzle, showing spinal disinhibition — disruption of the spinal cord’s inhibitory systems that modulate pain signals — in people with fibromyalgia syndrome. The results suggest that spinal disinhibition could be a mechanism for generating✱ pain in fibromyalgia.
These findings fit into much of the current thinking on chronic pain in people with fibromyalgia, says Roland Staud, MD, professor of medicine in the Department of Rheumatology at the University of Florida, Gainesville, Florida, who was not involved with this study.
“Regulation of sensitivity, including spinal cord sensitivity, is abnormal in these individuals,” he said….
✱ I would argue that it’s not generation, but amplification. And of course not of pain “signals” alone, since a lot of us experience the world as too loud, too bright, too abrasive, too odorous, too heavy, too unsteady, and so on.
h/t FloridaSNMOM
Sorry I’m not up for summarizing the entire article right now. Hoping a good comment thread can help us all get a good dive into this and other fibromyalgia material readers have found recently.
If you have links for sites or articles of value to fibromyalgics, please bring those to the thread too.
UPDATE
The need to recognize and manage chronic nociplastic pain has become integral to rheumatology practice, as research over the past half-decade has affirmed that when central sensitization is present, patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (AxSpA), and other rheumatologic diseases are less responsive — or nonresponsive — to peripherally and axially focused anti-inflammatory and immunomodulatory therapies.
Central sensitization is a key feature of nociplastic pain, a third pain category, or mechanistic description, so named in 2017 by the International Association for the Study of Pain (IASP). The pain community’s new category — joining nociceptive and neuropathic pain — came after researchers in rheumatology led the way with decades of research showing that fibromyalgia (FM) is centrally mediated, often without ongoing peripheral nociceptive input….
