The quest is to save the world's population from Bird flu. The knight in shining armor is Gilead,(a subsidiary of Roche) who makes the drug Tamiflu. Rumsfeld*, who was CEO of Gilead till 2001 when he became US Defense Secretary, stands to make millions in profit off this patented drug through contracts with governments to stockpile the "only effective" treatment.
Now another group of "knights" are developing a Genetically Modified Chicken, that will be resistant to bird flu. They hope to breed enough to replace the entire chicken population of the planet. Never mind that new flus develop every year and this chicken would only be resistance to the H5N1, in effect allowing the developer to monopolize the chicken market buy releasing new GMied chickens each year.
Scientists aim to beat flu with genetically modified chickens
By Mark Henderson, Science Correspondent
THE long-term threat of an avian flu pandemic could be greatly reduced by a project to produce genetically modified chickens that can resist lethal strains of the virus.
British scientists are genetically engineering chickens to protect them against the H5N1 virus that has devastated poultry farms in the Far East, with a view to replacing stocks with birds that are not susceptible to influenza.
The technique should also offer protection against many other strains of flu with the potential to start a human pandemic, such as the H7 subgroup that was responsible for an outbreak in Dutch poultry in 2003.
If chicken populations were to be replaced with transgenic birds that were resistant to flu, it would remove a reservoir of the virus and make it much harder for it to spread to humans and trigger a pandemic.
The team, led by Laurence Tiley, Professor of Molecular Virology at Cambridge University, and Helen Sang, of the Roslin Institute, near Edinburgh, has already shown that chicken cells can be protected against flu by inserting small pieces of genetic material.
The researchers are now ready to begin a similar procedure with eggs and the first experiments are expected within weeks. Any breakthrough, however, will come too late to have an impact on the present outbreak of H5N1.
Even if the technique works, it will be several years before it can be used to stock farms and it also faces important regulatory hurdles and a battle to win over public opinion. If these obstacles are overcome and farmers are willing to adopt GM chickens, the entire world stock could be replaced fairly quickly.
"Once we have regulatory approval, we believe it will only take between four and five years to breed enough chickens to replace the entire world population," Professor Tiley said. "Developing flu-resistant chickens has clear benefits for human health and animal welfare, as we wouldn't have to slaughter chickens around the world. Chickens provide a link between the wild bird population, where avian influenza thrives, and humans, where new pandemic strains can emerge. Removing that bridge will dramatically reduce the risk posed by avian viruses."
The research team is following three parallel approaches. One involves inserting a working copy of a gene that makes an antiviral protein called Mx, which is defective in many chicken breeds, and should improve their ability to fight off H5N1 and other strains.
The second approach is to harness a technique called RNA interference, in which small fragments of the genetic signalling chemical RNA are used to disrupt the workings of the flu virus.
By engineering chicken cells to make small RNA molecules that confuse the flu virus, the scientists hope to confer resistance to a wide variety of strains. The third strategy is similar to the second, but involves using RNA molecules as decoys, which trick the flu virus into copying them rather than itself. All three could potentially be incorporated in the same GM chickens.
[url]http://www.timesonline.co.uk/...[/url]
*Rumsfeld's Gilead story:
`Rummy Flu'
Tamiflu was developed and patented in 1996 by a California biotech firm, Gilead Sciences Inc. Gilead is a NASDAQ (GILD) listed stock company which prefers to maintain a low profile in the current rush to Tamiflu. That might be because of who is tied to Gilead. In 1997, before he became US Secretary of Defense, Donald H. Rumsfeld was named Chairman of the Board of Gilead Sciences, where he remained until early 2001 when he became Defense Secretary. Rumsfeld had been on the board of Gilead since 1988 according to a January 3 1997 company press release.
An as-yet-unconfirmed report is that Rumsfeld while Secretary of Defense also purchased an additional stock in his former company, Gilead Sciences Inc., worth $18 million, making him one of its largest if not the largest stock owners today.
The Secretary of Defense, the man who allegedly supported the use of contrived intelligence to justify the war on Iraq, is now poised to reap huge gains for a flu panic his Administration has done everything it can to promote. It would be useful to know whether the Pentagon's successor to Douglas Feith's Office of Special Plans developed the strategy of biowarfare behind the current Avian Flu panic. Perhaps some enterprising Congressional committee might look into the entire subject of plausible conflicts of interest regarding Secretary Rumsfeld.
Rumsfeld stands to make a fortune on royalties as a panicked world population scrambles to buy a drug worthless in curing effects of alleged Avian Flu. The model suggests the parallel to the brazen corruption of Halliburton Corporation whose former CEO is Vice President Dick Cheney. Cheney's company has so far gotten billions worth of US construction contracts in Iraq and elsewhere. Coincidence that Cheney's closest political friend is Defense Secretary and Avian Flu beneficiary Don Rumsfeld? It is another example of what someone has called the principle of modern US corrupt special interest politics: `Concentrate the benefits; diffuse the costs' President Bush has ordered the US Government to buy $2 billion worth of Gilead Science's Tamilflu.
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