AP and BBC are reporting that a suicide bomber has rammed a car full of explosives into the gates of the Indian embassy in the Afghan capital, killing 41 people and injuring 141.
Five embassy personnel were killed - India's defence attache, a senior diplomat and two security guards - as well as an Afghan man.
Five Afghans died at Indonesia's embassy nearby.
Bush administration's response:
In Washington, Gordon Johndroe, a White House national security spokesman, offered condolences to the victims.
"Extremists continue to show their disregard for all human life and their willingness to kill fellow Muslims as well as others," he said. "The United States stands with the people of Afghanistan and India as we face this common enemy."
So far Taleban has denied that it is responsible for the bombing.
This is not the only attack in Afghanistan today.
In two separate bombings Monday against police convoys in the country's south, seven officers were killed and 10 others were wounded, officials said.
In Uruzgan province, a roadside bomb killed four police on patrol and wounded seven others, said provincial police chief Juma Gul Himat.
In the Zhari district of Kandahar, another roadside blast killed three officers and wounded three others, said district chief Niyaz Mohammad Sarhadi.
NATO's International Security Assistance Force, meanwhile, said one of its soldiers died in an attack in the south on Sunday.
BBC has a timeline of recent attacks in Kabul:
April 2008: Gun attack on parade attended by President Karzai
March 2008: Six people die in car bomb attack on coalition convoy
Jan 2008: Six people killed in Taleban attack on Serena hotel
Dec 2007: At least 13 people killed in a suicide car bombing
Sept 2007: Suicide bomb attack on bus kills 30 Afghan soldiers
June 2007: Bomb attack on Afghan police bus kills up to 35 people
Another day in the life of Bush foreign policy and "war against terrorism" .