Drugs kill at least 30% of Americans.
You never hear this from drug policy reform groups because it shows that drugs are dangerous. And you never hear this from the government because it shows that our drug policies are a complete and utter failure.
Nevertheless, drug use and drug-related causes are the single largest underlying cause of death each year in the United States, as the government's own statistics show. Even if you don't consider yourself to be a drug user, all else being equal it's more likely that you'll die from drug use than from any other cause.
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